Zirconium tetraazamacrocycle complexes display extraordinary stability and provide a new strategy for zirconium-89-based radiopharmaceutical development.

Zirconium tetraazamacrocycle complexes display extraordinary stability and provide a new strategy for zirconium-89-based radiopharmaceutical development† †TJW, DNP and NB have filed patents relating to this work. All other authors declare no competing financial interests exist. ‡ ‡Electronic supplementary information (ESI) available: Complete experimental details and supporting data. CCDC 1501174. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc04128k Click here for additional data file. Click here for additional data file.

Synthesis and characterisation of zirconium complexes for cell tracking with Zr-89 by positron emission tomography.

The increasing availability of the long half-life positron emitter Zr-89 (half life 78.4 h) suggests that it is a strong candidate for cell labelling and hence cell tracking using positron emission tomography. The aim was to produce a range of neutral ZrL4 lipophilic complexes for cell labelling which could be prepared under radiopharmaceutical conditions. This was achieved when the ligand was ...

Diamido Complexes of Titanium and Zirconium as Catalyst Precursors for Ethylene Polymerization

A series of 8 new complexes of titanium and zirconium with diamido ligands bearing an ethylene and propylene bridge between the two amido groups were synthesized and tested for ethylene polymerization. Titanium complexes bearing an ethylene bridge between the two amido groups showed higher activities than the derivatives with a propylene bridge. In the case of the zirconium complexes, the p...

An octadentate bifunctional chelating agent for the development of stable zirconium-89 based molecular imaging probes.

(89)Zr-based imaging agents hold great promise as novel radio-tracers in nuclear medicine. However, insufficient stability of currently used radiometal complexes in vivo is a safety concern for clinical applications. We herein report the first octadentate bifunctional chelating agent for the development of (89)Zr-labelled (bio)conjugates with improved stability.

The effect of iodo substituents in bis(phenoxyimine) zirconium complexes on the catalytic performance of homogeneous ethylene polymerization reactions

Eight different zirconium phenoxyimine complexes were synthesized, characterized and tested as catalysts for ethylene polymerization. The phenoxyimine compounds were prepared by condensation of substituted salicylaldehydes with aliphatic and aromatic amines, the substituted salicylaldehydes from ortho substituted phenols and paraformaldehyde. The introduction of iodo substituents was achieved e...